Jay Schulkin's Allostasis, Homeostasis, and the Costs of Physiological PDF

By Jay Schulkin

ISBN-10: 0521811414

ISBN-13: 9780521811415

Unlike homeostasis, allostasis refers back to the particularly new suggestion of "viability via change." This e-book addresses uncomplicated physiological regulatory platforms, and examines physically law lower than duress. It integrates the elemental recommendations of physiological homeostasis with problems reminiscent of melancholy, tension, nervousness and dependancy. it's going to curiosity graduate scholars, scientific scholars, and researchers in body structure, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.

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Additional info for Allostasis, Homeostasis, and the Costs of Physiological Adaptation

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Hall). Section 1, Neurophysiology, Vol. 3 (section ed. H. W. Magovn). Washington, DC: American Physiological Society. Stellar, E. (1954). The physiology of motivation. Psychol Rev 61:5–22. , Corbit, J. D. (1973). Neural control of motivated behavior: A report based on an NRP work session. Neurosci Res Prog Bull 11:295–410. , Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In: Handbook of Life Stress, Cognition, and Health (eds. S. Fisher, J. Reason). New York: John Wiley & Sons.

Most biologists now agree that the true object of all the vital mechanisms is not “constancy” but survival to reproduce. So what all the vital mechanisms actually serve is reproductive success under natural selection. ” We now know that the conditions extend to amazing extremes: thermophilic bacteria can thrive at 100◦ C, and the limit Principles of Allostasis 23 for their successful culturing extends to 113◦ C! (Hochachka and Somero, 2002). Cell temperatures in the desert can fluctuate by nearly 100◦ C, and even in complex metazoans the pH of blood and cytosol varies systematically with temperature (Hochachka and Somero, 2002).

In the mid-1960s, canvassing door-to-door in the African American ghettos such as Central and Hough of Cleveland Ohio, I noticed that many people who answered my knock were partially paralyzed – faces sagging on one side, walking with a limp and a crutch. The cause was “stroke,” a rare affliction in my own community, and one that I never encountered later when canvassing in white, upper-class Brookline, Massachusetts. What caused so many strokes, I wondered, and how might they be connected to Cleveland’s racial segregation?

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Allostasis, Homeostasis, and the Costs of Physiological Adaptation by Jay Schulkin

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