By Panagiotis A. Tsonis
Not uncomplicated line drawings on a web page, molecular constructions can now be seen in full-figured glory, frequently in colour or even with interactive percentages. Anatomy of Gene rules is the 1st booklet to give the components and approaches of gene law on the three-d point. shiny buildings of nucleic acids and their spouse proteins are published in full-color, 3-dimensional shape. starting with a common advent to three-d constructions, the publication appears on the association of the genome, the constitution of DNA, DNA replication and transcription, splicing, protein synthesis, and supreme protein demise. all through, the textual content employs a dialogue of genetics and structural mechanics. The concise and designated synthesis of data will provide perception into gene rules, and into the advance of tips on how to intervene with law at diseased states. This textbook and its accompanying website are acceptable for either undergraduate and graduate scholars in genetics, molecular biology, structural biology, and biochemistry classes.
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Additional info for Anatomy of Gene Regulation: A Three-dimensional Structural Analysis
TELOMERES At the end of the chromosomes, DNA has a very unique sequence and structure, which constitute the telomeres. A telomere is a nucleoprotein. Specialized proteins interact with unique sequences and confer the structure and function of the telomeres. Telomeres are very important for stability of the end of the chromosomes and are made up of guanine-rich sequences, which are repeated many times. The sequence is [d(T2G4)n] in Tetrahymena, [d(T4G4)n] in Oxytricha, and [d(T2AG3)] in human. This sequence is bound by telomerase, a nucleoprotein that contains an RNA component with sequences complementary to the telomere sequences, and a protein component, which acts as reverse transcriptase.
Coli RecA protein (see later). The nucleotide (here is ADP)-binding site is located in 1A, and the DNA-binding site is in a cleft between subdomains 1B and 1A. The Rep monomer can exist as two conﬁgurations: an open and a closed one. 21B).
When the double-stranded DNA melts at the origin of replication to expose the single strands to the polymerizing enzyme, the fork must continue to unwind until the termination signals have been reached. This part in replication is performed by helicases, and the topology ahead of the fork (mainly coiling and superwinding of the DNA) is controlled by topoisomerases. Finally, termination is achieved by the interaction of both helicases and termination proteins. Editing is another important function during replication to ensure that misincorporations are eliminated and, thus, mutations are avoided.
Anatomy of Gene Regulation: A Three-dimensional Structural Analysis by Panagiotis A. Tsonis