Read e-book online Antiplatelet Therapy In Ischemic Heart Disease (American PDF

By Stephen D. Wiviott

ISBN-10: 1405176261

ISBN-13: 9781405176262

ISBN-10: 1444303341

ISBN-13: 9781444303346

* attracts from services of leaders in antiplatelet treatment* Easy-to-use structure allows speedy shopping* Edited by means of a member of the celebrated TIMI learn workforce with long-standing event within the box

Show description

Read or Download Antiplatelet Therapy In Ischemic Heart Disease (American Heart Association Clinical Series) PDF

Best cardiovascular books

Read e-book online Cardiac Care: An Introduction for Healthcare Professionals PDF

Written through skilled clinicians, Cardiac Care: An advent for Nurses takes readers step-by-step in the course of the sufferer trip, from preliminary prevention throughout the serious interval to rehabilitation or palliative care. A primary source for all these new to cardiac care, the ebook offers a uncomplicated grounding within the underlying pathophysiology of the ailment in addition to an knowing of accessible remedies and gives an available replace at the most recent study and tendencies within the cardiac distinctiveness.

Download PDF by Yasuhiko Sakata MD, PhD (auth.), Ichiro Wakabayashi, Klaus: Interdisciplinary Concepts in Cardiovascular Health: Volume

This e-book offers an creation to the rules of either cardiovascular epidemiology and molecular pathophysiology; as a different element, it additionally outlines and discusses the molecular innovations underlying epidemiological observations. This 3rd quantity is concentrated at the commonest “cardiovascular occasions” to supply an summary on pathogenesis and scientific facets.

Download e-book for iPad: MRI and CT of the Cardiovascular System by Charles B. Higgins, Albert de Roos MD

Go away no ailment undetected with MRI and CT of the Cardiovascular method, your definitive consultant to magnetic resonance and computed tomography for cardiovascular wellbeing and fitness. Authored by means of a collaboration of overseas specialists, this shiny, four-color 3rd variation imparts the newest applied sciences in a quickly advancing box.

Additional resources for Antiplatelet Therapy In Ischemic Heart Disease (American Heart Association Clinical Series)

Example text

The antithrombotic effect of aspirin is resultant from the decreased production of TXA2, a potent vasoconstrictor and platelet agonist. The Antithrombotic Trialists’ Collaboration reported that aspirin therapy was associated with 15% reduction in vascular mortality, 34% reduction in myocardial infarction, and 25% reduction in stroke among high-risk patients with atherothrombotic disease [2]. Aspirin has also been shown to reduce the acute ischemic complications of coronary angioplasty [3–5]. While the benefits of aspirin are widely accepted, cardiovascular events may still occur in patients treated with aspirin.

6). Comparison of the VASP assay with ADP-induced turbidometric platelet aggregation demonstrated that the level of thienopyridine-induced inhibition is higher in the VASP assay, presumably because platelet aggregation can still occur via ADP stimulation of P2Y1 in the presence of a thienopyridine [28]. Patients with a poorer platelet response to clopidogrel, as determined by the VASP assay, have been reported to have a higher incidence of subacute stent thrombosis [30]. Platelet surface P-selectin and/or the activated conformation of platelet surface GP IIb/IIIa (reported by monoclonal antibody PAC1) can also be measured by whole blood flow cytometry [31].

Pharmacodynamics ASA irreversibly inhibits the initial committed step of prostanoid biosynthesis by preventing the conversion of AA to PGG2 by COX-1 and COX-2. ASA initially binds an arginine 120 residue, a common docking site for all NSAIDs, after which it acetylates a COX serine residue [21]. In the human COX-1 enzyme, serine is acetylated at position 529 whereas in COX-2 this occurs at position 516 [21]. Acetylation of the serine residue by ASA stops AA from accessing the catalytic site of the COX [11] and prevents formation of the downstream prostanoids.

Download PDF sample

Antiplatelet Therapy In Ischemic Heart Disease (American Heart Association Clinical Series) by Stephen D. Wiviott

by Kenneth

Rated 4.67 of 5 – based on 47 votes