Physiology

Read e-book online BCL2 Protein Family: Essential Regulators of Cell Death PDF

By Claudio Hetz

ISBN-10: 1441967052

ISBN-13: 9781441967053

During this ebook, scientists pioneering the sphere have compiled a chain of centred chapters to spotlight the relevance of the BCL‑2 kinfolk of proteins in apoptosis, body structure and affliction. a big concentration of this quantity is thinking about the aptitude TH period PEUT IC merits of concentrating on apoptosis pathways within the context of human affliction. Readers attracted to knowing how a cellphone handles rigidity and the results of dysregulation of this method for human ailment will locate this ebook very beneficial. It makes an attempt to explain a desirable region of study the place body structure and biomedicine converge at assorted degrees, revealing a visit from the molecular law of apoptosis to the influence of this procedure to the body structure of an entire organism.

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17. Carre M, Andre N, Carles G et al. Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel. J Biol Chem 2002; 277(37):33664-33669. 18. Rostovtseva TK, Sheldon KL, Hassanzadeh E et al. Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proc Natl Acad Sci USA 2008; 105(48):18746-18751. 19. Xu X, Forbes JG, Colombini M. Actin modulates the gating of Neurospora crassa VDAC. J Membr Biol 2001; 180(1):73-81.

238 It is important to note that increased levels of ROS is not always associated with cell cycle arrest; indeed, select ROS are required for proliferation in certain cell types. 224 Differentiation The antiproliferative properties of BCL-2 and BCL-XL may directly instruct differentiation and cellular fate decisions. 244 These findings indicate that BCL-2 and BCL-XL initiate a specific cell fate program rather than playing a more permissive role due to their anti-apoptotic effects. Remarkably, grafting the BH4 sequence of BCL-XL onto BCL-2 was sufficient to activate the erythroid differentiation program, suggesting a role for the BH4 domain in lineage commitment.

Baines CP, Kaiser RA, Sheiko T et al. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 2007; 9(5):550-555. 11. Malia TJ, Wagner G. NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. Biochemistry 2007; 46(2):514-525. 12. Shimizu S, Narita M, Tsujimoto Y. BCL-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399(6735):483-487.

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BCL2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz


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