New PDF release: Brain Energetics and Neuronal Activity: Applications to fMRI

By Robert G. Shulman, Douglas L. Rothman

ISBN-10: 0470847204

ISBN-13: 9780470847206

Книга mind Energetics and Neuronal task: purposes to fMRI and medication mind Energetics and Neuronal job: purposes to fMRI and MedicineКниги Медицина Автор: RobertÿG. Shulman, Douglas L. Rothman Год издания: 2004 Формат: pdf Издат.:Wiley Страниц: 336 Размер: 4,8 ISBN: 0470847204 Язык: Английский0 (голосов: zero) Оценка:This publication is exclusive in linking in vivo 13C NMR measurements of neuronal job and energetics with functions to practical imaging and sure ailment states It presents a primary neurochemical rationalization of mind task appropriate to sensible imaging, theories of neuronal job and sickness states, e.g. epilepsy, psychiatric illnesses and developmental problems. Novel and in all probability debatable Will motivate destiny study instructions

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From Takahashi et al. (1995). Similar results were reported by Pellerin and Magistretti (1994). the 2–3 Na+ ions co-transported inward with each molecule of glutamate taken up, and one molecule of ATP is consumed in converting the molecule to glutamine, it appears that the net gain of two molecules of ATP from the glycolysis of one molecule of glucose is consumed in the processing of one molecule of glutamate by astroglia. 6. SUMMARY The main energy-consuming work of functionally activated neural tissues is related to the generation and propagation of action potentials and the disposition of the neurotransmitter molecules that are released at the synapses.

Law, M. , and Sokoloff, L. 1995. Role of sodium and potassium in regulation of glucose metabolism in cultured astroglia. Proc. Natl Acad. Sci. USA 92: 4616–4620. , and Magistretti, P. 1996. Metabolic coupling between glia and neurons. J. Neurosci. 16: 877–885. , Boyne, A. , and Brookes, N. 1986. Effect of monensin on deoxyglucose uptake in cultured astrocytes: energy metabolism is coupled to sodium entry. J. Neurosci. 6: 859–866. , and Sokoloff, L. 1983. Frequency-dependent activation of glucose utilization in the superior cervical ganglion by electrical stimulation of cervical sympathetic trunk.

Natl Acad. Sci. USA 91: 10625–10629. , and Hertz, L. 1994. High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes but have no stimulatory effect in a GABAergic neuronal culture. Brain Res. 663: 168–172. Phelps, M. , Huang, S. , Hoffman, E. , and Kuhl, D. E. 1979. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-d-glucose: validation of method. Ann. Neurol.

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Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine by Robert G. Shulman, Douglas L. Rothman

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