By Ihor Gussak, Charles Antzelevitch, Stephen C. Hammill, Win K. Shen, Preben Bjerregaard
A accomplished evaluation of the entire most modern advancements in cardiac electrophysiology, concentrating on either the medical and experimental facets of ventricular repolarization, together with newly came upon medical repolarization syndromes, electrocardiographic phenomena, and their correlation with the latest advances in simple technological know-how. The authors remove darkness from the elemental electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to express illness stipulations, and consider the way forward for antiarrhythmic drug improvement in keeping with either molecular and electrophysiological houses. in addition they totally evaluate the scientific presentation and administration of particular cardiac repolarization stipulations.
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Extra resources for Cardiac Repolarization (Contemporary Cardiology)
At the molecular level, the fact that some channels can reopen over this voltage range implies that there is a finite probability that inactivation is reversible even at depolarized voltages. Although the Na+ channel “window” current has been recognized as an important determinant of action potential duration in the heart for many years (21,22), recent studies focused on exploring the mechanisms underlying inherited cardiac arrhythmias have shown that voltage-gated Na+ channels play an important role in ventricular action potential repolarization.
In most voltage-gated Ca2+ channels, the α1 subunit determines the properties of the resulting channels. The transmembrane topology of Cavα1 subunits is similar to the Navα1subunits in that Cavα1 subunits comprise four homologous domains (domain I–IV), each of which is composed of six putative transmembrane segments (S1–S6), one of which is the “S4” voltage sensing domain, and a region between S5 and S6 that contributes to the Ca2+ selective pore (Fig. 2B). Also similar to voltage-gate Navα1 subunits (Fig.
2B). Also similar to voltage-gate Navα1 subunits (Fig. 2A), the N- and Ctermini of Cavα1 subunits are intracellular (Fig. 2B).
Cardiac Repolarization (Contemporary Cardiology) by Ihor Gussak, Charles Antzelevitch, Stephen C. Hammill, Win K. Shen, Preben Bjerregaard