By S. Dhein
In recent times, hole junction examine within the cardiovascular method has significantly better the certainty of cardiac functionality and the vasculature in future health and ailment. the current publication makes a speciality of the communique of intercellular hole junctions within the cardiovascular process but in addition contains elements of body structure, drugs and telephone biology. the 1st a part of this quantity highlights the imperative features of those intercellular channels, permitting the readers unusual with the sector to get a deeper knowing of the body structure, pharmacology and legislation of hole junctions. the second one half elucidates their position within the pathophysiology of vital cardiovascular illnesses, e.g. arrhythmia, middle failure, ischemia, atrial traumatic inflammation, diabetes and arteriosclerosis. This booklet is of certain curiosity to cardiologists, physiologists, pharmacologists, cardiovascular scientists, biophysicists, mobilephone biologists in addition to to commercial businesses engaged in cardiovascular drugs and learn.
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Extra resources for Cardiovascular Gap Junctions
J Cell Biol 1990;111:2077–2088. Physiology of Cardiovascular Gap Junctions 37 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 Musil LS, Goodenough DA: Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol 1991;115:1357–1374. Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF: Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol 2000;149:1503–1512.
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Within the physiologically relevant range of intracellular pCa and pH it is unlikely that Ca2ϩ or Hϩ independently strongly affect the conductive properties of Cx43 channels [42, 49]. However, in some cells there is evidence that gating behavior is affected by intracellular pH and pCa at near physiological concentrations, indicative of a regulatory mode relevant to normal cell function . Yet, a synergistic mechanism between Ca2ϩ and Hϩ that strengthens their effect on Cx43 channels could be of importance under conditions of cardiac ischemia when intracellular Ca2ϩ and Hϩ increase [51, 52].
Cardiovascular Gap Junctions by S. Dhein