By E. Edward Bittar (Eds.)
This quantity surveys the growth that has been made within the research of coronary angiogenesis and offers the reader with a common insurance of the advances within the middle wisdom within the box. it's transparent that as we achieve a deeper knowing of mechanisms underlying stimulation (and inhibition) of coronary angiogenisis, it will probably develop into attainable to enhance novel treatments for expanding the expansion and formation of collateral vessels within the ischemic center. even if learn within the area of angiogenesis is progressively forthcoming its golden age, the examine of coronary angiogenesis remains to be in its infancy.
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Extra info for Coronary Angiogenesis
ABSTRACT Vascular Endothelial Growth Factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models. The tyrosine kinases Flt-1 and KDR are high affinity receptors for VEGF. The pivotal role of VEGF in developmental angiogenesis is emphasized by the findings that loss of asingle VEGFallele results in defective vascularization and early embryonic lethality. Recent evidence indicates that VEGF is essential for angiogenesis in the female reproductive tract.
Furthermore, the concentrations of VEGF are elevated in the aqueous and vitreous humors of patients with proliferative disorder as compared with patients affected by non-neovascular disorder. In addition, VEGF-induced angiogenesis results in a therapeutic benefit in several animal models of myocardial or limb ischemia: collateral vessel growth and improved function follow VEGF administration. Currently, rhVEGF is in phase I1 clinical trials for the treatment of coronary ischemia. A humanized anti-VEGF monoclonal antibody is also in clinical trials as a therapy for various solid tumors.
92, 10457-10461. , , Ziche. , Bussolino, F. and Noonan, D. (1996a). HIV-tat protein is a heparin-binding angiogenic growth factor. Oncogene 12,289-297. and Bussolino, F. NatureMed. 2,1371-1375. H. W. (1945). Vascular reactions of n o d and malignant tissues in vivo. 1. Vascular recations of mice to wounds and to normal and neoplastic transplants. J. Natl. Cancer Inst. 73-85. , Stone, J. and Keshet. E. Vascularendothelialgrowth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity.
Coronary Angiogenesis by E. Edward Bittar (Eds.)