By Yasuhiko Sakata MD, PhD (auth.), Ichiro Wakabayashi, Klaus Groschner (eds.)
This booklet offers an creation to the foundations of either cardiovascular epidemiology and molecular pathophysiology; as a special point, it additionally outlines and discusses the molecular strategies underlying epidemiological observations. This 3rd quantity is concentrated at the most typical “cardiovascular occasions” to supply an summary on pathogenesis and scientific features. The e-book promotes using interdisciplinary ways within the box of preventive medication in keeping with contemporary advances in molecular and mobile pathophysiology. The booklet bargains a precious source for researchers in easy biomedical fields and scientific scientists alike, in addition to guidance for novel avenues of analysis in either uncomplicated pathophysiology and cardiovascular treatment and prevention.
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Additional resources for Interdisciplinary Concepts in Cardiovascular Health: Volume III: Cardiovascular Events
However, although the association of a moderately high level of LDL cholesterol with ischemic stroke is controversial, there is a clear association between LDL cholesterol levels and coronary heart disease (Prospective Studies Collaboration et al. 2007). Rather, a low level of high-density lipoprotein (HDL) cholesterol has been shown to be related to ischemic stroke (Soyama et al. 2003). In contrast to controversies over the association between lipid level and ischemic stroke, statin treatment has been shown to be associated with primary prevention of ischemic stroke by meta-analysis (Baigent et al.
In Japan, intravenous administration of argatroban, a direct inhibitor of thrombin (LaMonte et al. 2004), and edaravone, a free radical scavenger (Edaravone Acute Infarction Study Group 2003), are approved for acute ischemic stroke. In cases of massive cerebral infarction, surgical decompression has been shown to be beneficial in patients with consciousness disturbance and signs of central or uncal herniation (Adams et al. 2007). For massive hematoma, surgical evacuation is recommended in patients with consciousness disturbance and signs of compression of the brain stem after cerebellar and subcortical hemorrhage.
However, recently developed brain imaging techniques can identify small fresh lesions even if symptoms disappear within 24 h. The definition of ischemic stroke and transient ischemic attack (TIA) is still under debate. However, tissue-based diagnosis is becoming popular for stroke diagnosis (Easton et al. 2009). Stroke can be classified as cerebral infarction, intracerebral hemorrhage, or SAH (Fig. 3). The term cerebral infarction indicates an ischemic stroke caused by occlusion of extracerebral or intracerebral arteries.
Interdisciplinary Concepts in Cardiovascular Health: Volume III: Cardiovascular Events by Yasuhiko Sakata MD, PhD (auth.), Ichiro Wakabayashi, Klaus Groschner (eds.)