By Valérie Gabelica (eds.)
This booklet offers actual chemists a broader view of strength organic purposes in their recommendations for the learn of nucleic acids within the fuel section. It offers natural chemists, biophysicists, and pharmacologists with an advent to new recommendations they could use to discover the solutions to but unsolved questions. Laboratory sciences have bloomed with a number of thoughts to decipher the houses of the molecules of existence. This quantity introduces concepts used to enquire the homes of nucleic acids within the absence of solvent. It highlights the specificities bearing on the stories of nucleic acids, even though a few of the suggestions can equally be utilized to the research of alternative biomolecules, like proteins. the 1st a part of the ebook introduces the recommendations, from the move of nucleic acids to the gas-phase, to their designated physico-chemical research. each one bankruptcy is dedicated to a selected molecular estate, and illustrates how a number of methods (experimental and theoretical) may be mixed for the interpretation.
The moment a part of the ebook is dedicated to utilising the gas-phase methods to unravel particular questions relating to the biophysics, biochemistry or pharmacology of nucleic acids.
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Additional resources for Nucleic Acids in the Gas Phase
Gueron M, Leroy JL (2000) The i-motif in nucleic acids. Curr Opin Struct Biol 10:326–331 10. Drew H, Wing R, Takano T, Broka C, Tanaka S, Itakura K, Dickerson RE (1981) Proc Natl Acad Sci USA:2179–2183 11. Radhakrishnan I, Patel DJ (1994) Solution structure of a pyrimidine-purine-pyrimidine DNA triplex containing T*AT, C+*GC and G*TA triples. Structure 2:17–32 12. Creze C, Rinaldi B, Haser R, Bouvet P, Gouet P (2007) Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions. Acta Crystallogr 63:682–688 13.
The droplets pass downstream a skimmer to enter a pick up cell filled with the species to be embedded (Fig. 5). Superfluid helium droplets are known to efficiently pick up molecules due to the large collision cross section of roughly ˚ 2, where N is the average number of helium atoms forming the droplet. 15 N2/3 A Therefore, a vapor pressure of only 10À5–10À6 mbar is sufficient for picking up a single particle on average, which is particularly well suited for species with low volatility such as DNA bases.
It is commonly accepted that “false positives” can be easily avoided by applying proper experimental conditions (in particular with low analyte concentrations). However, “false negatives” has to be carefully checked and viewed with caution since complex stability may be greatly affected in the gas phase and/or if electrospray conditions or instrument tuning in the ion transfer region are too harsh. The typical solvent conditions used in ESI-MS to achieve maximum sensitivity are not always optimal for maintaining an intact biomolecular complex.
Nucleic Acids in the Gas Phase by Valérie Gabelica (eds.)